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Olmutinib

CAS No. : 1353550-13-6

MCE 国际站：Olmutinib

产品活性：Olmutinib (HM61713; BI-1482694) 是口服有效的，不可逆的第三代 EGFR 酪氨酸激酶抑制剂，其与激酶结构域附近的半胱氨酸残基结合。Olmutinib 可用于非小细胞肺癌的研究。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK

作用靶点：EGFR

In Vitro: Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFR^DEL19 (IC₅₀=9.2 nM) and H1975 cells expressing EGFR^L858R/T790M (IC₅₀=10 nM). In contrast, the IC₅₀ of olmutinib against cells expressing EGFR^WT is 2225 nM.

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