FITC标记的PDZ结构域蛋白GOPC抗体
产品名称： FITC标记的PDZ结构域蛋白GOPC抗体
英文名称： Anti-PIST/FITC
产品编号： HZ-11253R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PIST/FITC Conjugated antibody
FITC标记的PDZ结构域蛋白GOPC抗体
| 产品编号 | bs-11253R-FITC |
| 英文名称 | Anti-PIST/FITC |
| 中文名称 | FITC标记的PDZ结构域蛋白GOPC抗体 |
| 别 名 | CAL; GOPC; CFTR associated ligand; CFTR-associated ligand; FIG; Fused in glioblastoma; Golgi associated PDZ and coiled coil motif containing; Golgi associated PDZ and coiled coil motif containing protein; Golgi-associated PDZ and coiled-coil motif-containing protein; GOPC_HUMAN; GOPC1; OTTHUMP00000040403; PDZ protein interacting specifically with TC 10; PDZ protein interacting specifically with TC10; PDZ/coiled coil domain binding partner for the rho family GTPase TC 10; PDZ/coiled coil domain binding partner for the rho family GTPase TC10; PIST; Protein interacting specifically with Tc 10; Protein interacting specifically with Tc10; dJ94G16.2; dJ94G16.2 PIST. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PIST |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PIST (PDZ protein interacting specifically with TC10), also known as GOPC (golgi associated PDZ and coiled-coil motif containing), CAL or FIG, is a 462 amino acid protein that localizes to the cytoplasm, as well as to the membrane of the golgi apparatus and to the cell junction. Expressed ubiquitously and containing one PDZ (DHR) domain, PIST functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, PIST is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding PIST are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Three isoforms of PIST exist due to alternative splicing events. Function: Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. Subunit: Homooligomer. Interacts with FZD5, FZD8, GRID2, BECN1, CSPG5 and CLCN3. May interact with CACNG2 (By similarity). Interacts with STX6, CFTR, ASIC3, GOLGA3, NLGN1 and RHOQ. Subcellular Location: Cytoplasm. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. Tissue Specificity: Ubiquitously expressed. DISEASE: Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity. Similarity: Contains 1 PDZ (DHR) domain. Database links: Entrez Gene: 57120 Human Entrez Gene: 94221 Mouse Entrez Gene: 309774 Rat Omim: 606845 Human SwissProt: Q9HD26 Human SwissProt: Q3TAF1 Mouse SwissProt: Q8BH60 Mouse Unigene: 191539 Human Unigene: 390258 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PIST（PDZ蛋白特异性与TC10相互作用），也称为GOPC（高尔基相关PDZ和卷曲螺旋基序），CAL或FIG，是462种氨基酸蛋白，定位于细胞质，以及高尔基体膜和细胞连接处。pIST表达广泛，并含有一个PDZ（DHR）结构域，其功能是与多种蛋白质相互作用并在细胞内蛋白质转运和降解中发挥作用的同寡聚体。此外，PIST被认为通过膜通道修饰调节离子电流，也可能在自噬中起作用。PIST基因的染色体畸变在胶质母细胞瘤（GBM）中发现，这是一种常见的侵袭性脑肿瘤，提示突变型PIST在肿瘤发生中的作用。PIST的三种异构体由于选择性剪接事件而存在。