FITC标记的β晶体蛋白B1抗体
产品名称： FITC标记的β晶体蛋白B1抗体
英文名称： Anti-beta B1 Crystallin/FITC
产品编号： HZ-12582R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-beta B1 Crystallin/FITC Conjugated antibody
FITC标记的β晶体蛋白B1抗体
| 英文名称 | Anti-beta B1 Crystallin/FITC |
| 中文名称 | FITC标记的β晶体蛋白B1抗体 |
| 别 名 | Beta crystallin B1; Beta-B1 crystallin; Beta-crystallin B1; CRBB1_HUMAN; CRYBB 1; Crybb1; Crystallin beta B1; Eye lens structural protein; OTTHUMP00000028719. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human beta B1 Crystallin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into Alpha, Beta, and Gamma families, and the Beta- and Gamma-crystallins also comprise a superfamily. Crystallins usually contain seven distinctive protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins constitute the major lens structural proteins, and they associate into dimers, tetramers, and higher order aggregates. The Beta-crystallin subfamily is composed of several gene products, including Beta A1-, Beta A2-, Beta A3-, Beta A4-, Beta B1-, Beta B2- and Beta B3-crystallin. The Beta A1- and Beta A3-crystallin proteins are encoded by a single mRNA. They differ by only 17 amino acids, and Beta A1-crystallin is generated by use of an alternate translation initiation site. Function: Crystallins are the dominant structural components of the vertebrate eye lens. Subunit: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. Post-translational modifications: Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization. DISEASE: Defects in CRYBB1 are the cause of cataract congenital nuclear autosomal recessive type 3 (CATCN3) [MIM:611544]. A congenital cataract affecting the central nucleus of the eye. Nuclear cataracts are often not highly visually significant. The density of the opacities varies greatly from fine dots to a dense, white and chalk-like, central cataract. The condition is usually bilateral. Nuclear cataracts are often combined with opacified cortical fibers encircling the nuclear opacity, which are referred to as cortical riders. Defects in CRYBB1 are a cause of cataract-microcornea syndrome (CAMIS) [MIM:116150]. An ocular disorder characterized by the association of congenital cataract and microcornea without any other systemic anomaly or dysmorphism. Clinical findings include a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye, and an inherited cataract, which is most often bilateral posterior polar with opacification in the lens periphery. The cataract progresses to form a total cataract after visual maturity has been achieved, requiring cataract extraction in the first to third decade of life. Microcornea-cataract syndrome can be associated with other rare ocular manifestations, including myopia, iris coloboma, sclerocornea and Peters anomaly. Transmission is in most cases autosomal dominant, but cases of autosomal recessive transmission have recently been described. Similarity: Belongs to the beta/gamma-crystallin family. Contains 4 beta/gamma crystallin 'Greek key' domains. Database links: UniProtKB/Swiss-Prot: P53674.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
晶体是脊椎动物眼睛晶状体的主要蛋白质，它们维持晶状体的透明度和折射率。晶状体被分为α、β和γ家族，β-和γ-晶状体蛋白也包括超家族。结晶蛋白通常包含七个独特的蛋白质区域，包括四个同源基序，一个连接肽，以及N端和C端延伸。β-结晶蛋白是主要的晶状体结构蛋白，它们结合成二聚体、四聚体和高阶聚集体。β-晶体蛋白亚家族由多种基因产物组成，包括βA1-、βA2-、βA3-、βA4-、βB1-、βB2-和βB3-晶体蛋白。β-A1和β-A3晶状体蛋白由单个mRNA编码。它们仅相差17个氨基酸，并且β- A1晶状体蛋白通过使用另一个翻译起始位点而生成。