Anti-FGFR3 Polyclonal Antibody
品牌：Solarbio | 货号：K001684P



英文名称
Anti-FGFR3 Polyclonal Antibody
宿主
Rabbit
别名
ACH;CD333;CEK2;HSFGFR3EX;JTK4
应用
WB IHC
稀释比例
WB 1:500-1:2000. IHC 1:50-1:100.
交叉反应
Human Mouse Rat
蛋白分子量
88kDa
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
Recombinant protein of human FGFR3
Subcellular 
Locations
Cell membrane Cytoplasmic vesicle Endoplasmic reticulum 
Secreted Single-pass type I membrane protein
Swiss Prot
P22607
克隆类型
Polyclonal Antibody
背景资料
This gene encodes a member of the fibroblast growth factor 
receptor (FGFR) family, with its amino acid sequence being 
highly conserved between members and among divergent 
species. FGFR family members differ from one another in 
their ligand affinities and tissue distribution. A full-length 
representative protein would consist of an extracellular 
region, composed of three immunoglobulin-like domains, a 
single hydrophobic membrane-spanning segment and a 
cytoplasmic tyrosine kinase domain. The extracellular portion 
of the protein interacts with fibroblast growth factors, setting 
in motion a cascade of downstream signals, ultimately 
influencing mitogenesis and differentiation. This particular 
family member binds acidic and basic fibroblast growth 
hormone and plays a role in bone development and 
maintenance. Mutations in this gene lead to craniosynostosis 
and multiple types of skeletal dysplasia. Three alternatively 
spliced transcript variants that encode different protein 
isoforms have been described.