FITC标记的p53诱导核蛋白1抗体
产品名称： FITC标记的p53诱导核蛋白1抗体
英文名称： Anti-p53 DINP1/FITC
产品编号： HZ-6146R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-p53 DINP1/FITC Conjugated antibody
FITC标记的p53诱导核蛋白1抗体
| 英文名称 | Anti-p53 DINP1/FITC |
| 中文名称 | FITC标记的p53诱导核蛋白1抗体 |
| 别 名 | DKFZp434M1317 antibody FLJ22139 antibody p53 damage inducible nuclear protein 1 antibody p53 dependent damage inducible nuclear protein 1 antibody p53 inducible nuclear protein 1 antibody p53 inducible p53DINP1 antibody p53-dependent damage-inducible nuclear protein 1; p53DINP1; SIP; Stress induced protein; Stress-induced protein; T53I1_HUMAN; Teap; TP53 DINP1; TP53 INP1; TP53DINP1; TP53INP1; TP53INP1A; TP53INP1B; Tumor protein p53 inducible nuclear protein 1; Tumor protein p53-inducible nuclear protein 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞凋亡 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human p53 DINP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Function: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. Subunit: nteracts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B AND MAP1LC3C. Subcellular Location: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. Tissue Specificity: Ubiquitously expressed. Database links: Entrez Gene: 94241 Human Entrez Gene: 60599 Mouse Entrez Gene: 297822 Rat Omim: 606185 Human SwissProt: Q96A56 Human SwissProt: Q9QXE4 Mouse SwissProt: Q80YE2 Rat Unigene: 492261 Human Unigene: 393018 Mouse Unigene: 48267 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
抗增殖和促凋亡蛋白参与细胞应激反应，作为转录和自噬的双重调节。作为自噬的正调控因子。响应于细胞应激或自噬的激活，重新定位到自噬体，其中它与自噬体相关蛋白GABARAP、GABARAPL1/L2、MAP1LC3A/B/C相互作用，并调节自噬。作为抗氧化剂，在P53／TP53驱动的氧化应激反应中起重要作用。同时具有P53／Tp53独立的细胞内活性氧（ROS）调节功能和P53／TP53依赖的转录调节功能。P53／TP53和P73／Tp73阳性表达，刺激其诱导细胞凋亡和调节细胞周期的能力。响应于双链DNA断裂，促进Per-/Tp53在“Ser-46”和随后的细胞凋亡上的磷酸化。通过自噬和半胱天冬酶依赖的机制诱导肿瘤细胞死亡。可通过调节SPARC的表达减少细胞迁移。