http://www.creativebiomart.net/description_382929_12.htm

The leukocyte adhesion molecule DNAM1, also known as CD226, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. DNAM1 is identified as an intercellular adhesion molecule which are constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes/macrophages, and a subset of B lymphocytes. The poliovirus receptor (PVR or CD155) and its family member nectin 2 (CD112) have been identified as the ligands for DNAM1. Interaction of DNAM1 with the ligands induces NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. DNAM1 also plays an important role in immune surveillance of tumor development and is involved in triggering naive T cell differentiation and proliferation. Similarly, murine DNAM1 and PVR homologues physically and functionally bind each other in vivo, and ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells. Within the ECD, mouse DNAM1 shares 52% and 86% aa sequence identity with human and rat DNAM1, respectively.