FITC标记的ATP酶2C2抗体
产品名称： FITC标记的ATP酶2C2抗体
英文名称： Anti-SPCA2/FITC
产品编号： HZ-17639R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SPCA2/FITC Conjugated antibody
FITC标记的ATP酶2C2抗体
| 英文名称 | Anti-SPCA2/FITC |
| 中文名称 | FITC标记的ATP酶2C2抗体 |
| 别 名 | AT2C2_HUMAN; ATP2C2; ATPase 2C2; ATPase, Ca++ transporting, type 2C, member 2; Calcium-transporting ATPase type 2C member 2; DKFZp686H22230; hSPCA2; KIAA0703; PMR1; Secretory pathway Ca(2+)-ATPase 2; secretory pathway calcium ATPase 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 103kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPCA2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The family of P-type Ca2+-transport ATPases is made up of three subfamilies: sarco(endo)plasmic-reticulum Ca2+ ATPases (SERCA), plasma- membrane Ca2+ ATPases (PMCA), and secretory-pathway Ca2+ ATPases (SPCA). The SPCA1 protein (encoded for by the ATP2C1 gene) is a Ca2+/ Mn2+-transport ATPase. It localizes to the Golgi apparatus and, together with SERCA2, it is responsible for the ionic milieu in the Golgi lumen. SPCA2 (encoded by the ATP2C2 gene) also localizes to the golgi apparatus and has a higher enzymatic turnover rate than that of SPCA1 while having a high affinity for cytosolic Ca2+. The enzymatic properties of the human SPCA2 enzyme and the restriction of its tissue expression to the gastrointestinal and respiratory tracts, prostate, thyroid, salivary, and mammary glands may, in principle ,define a Ca2+-ATPase pump with a specific physiological role in secretory cells. Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Subcellular Location: Membrane. Tissue Specificity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. Similarity: Belongs to the cation transport ATPase (P-type) (TC3.A.3) family. Type IIA subfamily. Database links: Entrez Gene: 9914 Human Entrez Gene: 69047 Mouse Entrez Gene: 171496 Rat Omim: 613082 Human SwissProt: O75185 Human SwissProt: A7L9Z8 Mouse SwissProt: Q8R4C1 Rat Unigene: 6168 Human Unigene: 46251 Mouse Unigene: 163411 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
P型钙转运ATP酶家族由三个亚家族组成：肌浆网Ca2+ATP酶（SERCA）、质膜Ca2+ATP酶（PMCA）和分泌途径Ca2+ATP酶（SPCA）。SPCA1蛋白（由AT2C1基因编码）是Ca2+/Mn2+转运ATPase。它定位于高尔基体，并与SerCa2一起，它负责高尔基体腔中的离子环境。SPCA2(由ATP2C2基因编码)也定位于高尔基体，与SPCA1相比具有更高的酶促周转率，同时对胞浆Ca2+具有高亲和力。人SPCA2酶的酶学特性及其组织表达对胃肠道和呼吸道、前列腺、甲状腺、唾液和乳腺的限制，原则上可以定义在分泌细胞中具有特定生理作用的Ca2+-ATPase泵。