FITC标记的锌指蛋白426抗体
产品名称： FITC标记的锌指蛋白426抗体
英文名称： Anti-ZNF426/FITC
产品编号： HZ-12219R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZNF426/FITC Conjugated antibody
FITC标记的锌指蛋白426抗体
| 英文名称 | Anti-ZNF426/FITC |
| 中文名称 | FITC标记的锌指蛋白426抗体 |
| 别 名 | HGNC:20725; MGC2663; zinc finger protein 426; ZN426_HUMAN; Znf426. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human ZNF426 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF426 (Zinc finger protein 426), also known as MGC2663, is a 554 amino acid protein that is thought to be involved in transcriptional regulation. Localized to the nucleus, ZNF426 contains one KRAB domain and 12 C2H2-type zinc fingers through which it may convey DNA, RNA and protein binding capabilities. Specifically, ZNF426 may interact with the viral protein KSHV ORF 50 and, through this interaction, may activate viral gene transcription. Function: May be involved in transcriptional regulation. Subcellular Location: Nucleus. Similarity: Contains 12 C2H2-type zinc fingers. Contains 1 KRAB domain. Database links: Entrez Gene: 79088 Human Entrez Gene: 235028 Mouse Entrez Gene: 690895 Rat SwissProt: Q9BUY5 Human SwissProt: Q8R1D1 Mouse SwissProt: A1L1L7 Rat Unigene: 594011 Human Unigene: 297660 Mouse Unigene: 120278 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
锌指蛋白含有DNA结合结构域，具有多种功能，其中大多数包含某种形式的转录激活或抑制。大多数锌指蛋白包含Krüppel型DNA结合域和KRAB域，它们被认为与KAP1相互作用，从而募集组蛋白修饰蛋白。ZNF426（锌指蛋白426），也称为MGC2663，是一种554个氨基酸的蛋白质，被认为参与转录调节。ZNF426定位于细胞核，包含一个KRAB结构域和12个C2H2型锌指，通过它们可以传递DNA、RNA和蛋白质结合能力。具体而言，ZNF426可以与病毒蛋白KSHV ORF 50相互作用，并且通过这种相互作用，可以激活病毒基因转录。