Uniprot ID:O15296
Species Reactivity:Human
Antibody type:Polyclonal Antibody
Aliases:15-LOX-B,15-lipoxygenase 2,15-LOX-2,Arachidonate 15-lipoxygenase type II,Linoleate 13-lipoxygenase 15-LOb,ALOX15BRaised in:Rabbit
Background\Function :Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
Stroage Buffer:Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity:Caprylic Acid Ammonium Sulfate Precipitation purified
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