_{Recombinant Human VEGF165}

Catalog Number:

100-20

Synonyms:

Vascular Endothelial Growth Factor, VPF, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen

Description:

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase （flt-1）, KDR gene product （the murine homolog of KDR is the flk-1 gene product） and the flt4 gene product. Recombinant human VEGF₁₆₅ is a 38.2 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

AA Sequence:

APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells （HUVEC） using a concentration range of 1.0-8.0 ng/ml.

Cross Reactivity:

Cow, Green Algae, Guinea Pig, Hamster, Mouse, Pig, Rabbit, Rat, Sheep, Trout, Human, Chicken, Leech, Zebra Fish Embryo, Gelatin Microparticles, Rat + Chicken

Research Interests:

	Angiogenesis/ Cardiovascular		Cancer
	Inflammation		Proliferation

Country of Origin:

USA

Research Use Only. Not for use in diagnostic or therapeutic procedures.