SDHB/CEN1p FISH Probe
产品名称: SDHB/CEN1p FISH Probe
英文名称: SDHB/CEN1p FISH Probe
产品编号: FG0039
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
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- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Note:
Hybridization position of the probes on the chromosome.-
- Probe 1:
Size:
Fluorophore:
Location: - SDHB
Approximately 400kb
Texas Red
1p36.13
- Probe 2:
Size:
Fluorophore:
Location: - CEN1p
Approximately 780kb
FITC
1p13.3
- Probe Gap:
- The gap between two probes is approximately 92,300 kb
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge this image
- Human renal cell carcinoma (FFPE) stained with SDHB/CEN1p FISH Probe . Human renal cancer showed no SDHB gene amplification.
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Entrez GeneID:
- 6390
- Gene Name:
- SDHB
- Gene Alias:
- FLJ92337,IP,PGL4,SDH,SDH1,SDHIP
- Gene Description:
- succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq
- Other Designations:
- OTTHUMP00000002396,OTTHUMP00000044624,iron-sulfur subunit
- Gene Pathway
- Alzheimer's disease
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Huntington's disease
- Metabolic pathways
- Oxidative phosphorylation
- Parkinson's disease
- Related Disease
- Abdominal Neoplasms
- Adrenal Gland Neoplasms
- Bone Neoplasms
- Carcinoma, Medullary
- Carcinoma, Renal Cell
- Cardiovascular Diseases
- Carotid Body Tumor
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Glomus Jugulare Tumor
- Glomus Tumor
- Hamartoma Syndrome, Multiple
- Head and Neck Neoplasms
- Hippel-Lindau Disease
- Infertility, Male
- Kidney Neoplasms
- Lymphatic Metastasis
- Multiple endocrine neoplasia