TP53 monoclonal antibody, clone S11-K-抗体-抗体-生物在线

产品名称： TP53 monoclonal antibody, clone S11-K

英文名称： TP53 monoclonal antibody, clone S11-K

产品编号： MAB1626

产品价格： null

产品产地：台湾

品牌商标： Abnova

更新时间： null

使用范围：

亚诺法生技股份有限公司（Abnova)

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Recommend Usage:
Western Blot (1:2000)
ELISA (1:10000-1:20000)
The optimal working dilution should be determined by the end user.

Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Western Blot (Tissue lysate)
TP53 monoclonal antibody, clone S11-K (Cat # MAB1626). Western blot of TP53 in mouse brain crude lysate (50 ug of protein loaded).

Immunofluorescence
Immunofluorescence staining of HEK293 cells with TP53 monoclonal antibody, clone S11-K (Cat # MAB1626) at 1:200 dilution.

Gene Summary:
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq

Other Designations:
p53 antigen,p53 transformation suppressor,p53 tumor suppressor,phosphoprotein p53,transformation-related protein 53